Article
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature - 13 Aug 2009
Sanada Masashi, Suzuki Takahiro, Shih Lee-Yung, Otsu Makoto, Kato Motohiro, Yamazaki Satoshi, Tamura Azusa, Honda Hiroaki, Sakata-Yanagimoto Mamiko, Kumano Keiki, Oda Hideaki, Yamagata Tetsuya, Takita Junko, Gotoh Noriko, Nakazaki Kumi, Kawamata Norihiko, Onodera Masafumi, Nobuyoshi Masaharu, Hayashi Yasuhide, Harada Hiroshi, Kurokawa Mineo, Chiba Shigeru, Mori Hiraku, Ozawa Keiya, Omine Mitsuhiro, Hirai Hisamaru, Nakauchi Hiromitsu, Koeffler H Phillip, Ogawa Seishi
Abstract excerpt
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mu...
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