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Article

Mutations of c-Cbl in myeloid malignancies.

Oncotarget - 10 May 2015

Katzav Shulamit, Schmitz M Lienhard

Abstract excerpt

Next generation sequencing has shown the frequent occurrence of point mutations in the ubiquitin E3 ligase c-Cbl in myeloid malignancies. Mouse models revealed a causal contribution of c-Cbl for the onset of such neoplasms. The point mutations typically cluster in the linker region and RING finger domain and affect both alleles by acquired uniparental disomy. The fast progress in the detection of c-Cbl mutations...

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Identifiers

PMID: 26028666
DOI: 10.18632/oncotarget.3986
PMCID: PMC4484412

Genes

NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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