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Article

Role of CBL Mutations in Cancer and Non-Malignant Phenotype

8 Feb 2022

Abstract excerpt

CBL plays a key role in different cell pathways, mainly related to cancer onset and progression, hematopoietic development and T cell receptor regulation. Somatic CBL mutations have been reported in a variety of malignancies, ranging from acute myeloid leukemia to lung cancer. Growing evidence have defined the clinical spectrum of germline CBL mutations configuring the so-called CBL syndrome; a...

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PMID: 35159106
DOI: 10.3390/cancers14030839

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