CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

doi:10.1158/1078-0432.CCR-08-1325

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Article

CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009

Reindl Carola, Quentmeier Hilmar, Petropoulos Konstantin, Greif Philipp A, Benthaus Tobias, Argiropoulos Bob, Mellert Gudrun, Vempati Sridhar, Duyster Justus, Buske Christian, Bohlander Stefan K, Humphries Keith R, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

PURPOSE: CBL is a negative regulator of activated receptor tyrosine kinases (RTK). In this study, we determined the frequency of CBL mutations in acute leukemias and evaluated the oncogenic potential of mutant CBL. EXPERIMENTAL DESIGN: The cDNA of 300 acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and acute lymphoblastic leukemia (ALL) patients and 82 human leukemic cell lines was screened for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 11

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Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

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Share to Proto-Oncogene Proteins c-cbl

Source

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Identifiers

PMID: 19276253
DOI: 10.1158/1078-0432.CCR-08-1325

Genes

CBL
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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