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Article

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Dec 2009

Makishima Hideki, Cazzolli Heather, Szpurka Hadrian, Dunbar Andrew, Tiu Ramon, Huh Jungwon, Muramatsu Hideki, O'Keefe Christine, Hsi Eric, Paquette Ronald L, Kojima Seiji, List Alan F, Sekeres Mikkael A, McDevitt Michael A, Maciejewski Jaroslaw P

Abstract excerpt

PURPOSE: Acquired somatic uniparental disomy (UPD) is commonly observed in myelodysplastic syndromes (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), or secondary acute myelogenous leukemia (sAML) and may point toward genes harboring mutations. Recurrent UPD11q led to identification...

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Share to Chromosomes, Human, Pair 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19901108
DOI: 10.1200/JCO.2009.23.7503
PMCID: PMC3040009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19901108-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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