Loss of function Cbl-c mutations in solid tumors

doi:10.1371/journal.pone.0219143

Article

Loss of function Cbl-c mutations in solid tumors

1 Jul 2019

Abstract excerpt

Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are a family of RING finger (RF) ubiquitin ligases that negatively regulate a variety of RTKs, including EGFR, MET, and RET. Recent studies have identified Cbl mutations associated with human myeloid neoplasias in...

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