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MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication

18 Aug 2020

Abstract excerpt

Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers remain the most common deadly disease worldwide. The aberrant DNA replication serves as a major source of genomic instability and enhances cell proliferation that contributes to tumor initiation and progression. Minichromosome maintenance family (MCMs) is a well-recognized group of proteins responsible for DNA synthesis....

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PMID: 32822825
DOI: 10.1016/j.bbcan.2020.188415

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