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Article

Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast.

Molecular biology of the cell - 1 Oct 2015

Sabatinos Sarah A, Ranatunga Nimna S, Yuan Ji-Ping, Green Marc D, Forsburg Susan L

Abstract excerpt

DNA replication stress causes genome mutations, rearrangements, and chromosome missegregation, which are implicated in cancer. We analyze a fission yeast mutant that is unable to complete S phase due to a defective subunit of the MCM helicase. Despite underreplicated and damaged DNA, these cells evade the G2 damage checkpoint to form ultrafine bridges, fragmented centromeres, and uneven chromosome segregations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26246602
DOI: 10.1091/mbc.E15-05-0318
PMCID: PMC4591689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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