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The role of pre‐replicative complex (pre‐RC) components in oncogenesis

9 Aug 2007

Abstract excerpt

Normal DNA replication is stringently regulated to ensure a timely occurrence no more than once per cell cycle. Abrogation of the exquisite control mechanisms that maintain this process results in detrimental gains and losses of genomic DNA commonly seen in cancer and developmental defects. Replication initiation proteins, known as prereplicative complex (pre-RC) proteins, serve as a primary level of regulation,...

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PMID: 17690155
DOI: 10.1096/fj.07-8900rev

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