Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The presence of extra chromosomes leads to genomic instability.

Nature communications - 15 Feb 2016

Passerini Verena, Ozeri-Galai Efrat, de Pagter Mirjam S, Donnelly Neysan, Schmalbrock Sarah, Kloosterman Wigard P, Kerem Batsheva, Storchová Zuzana

Abstract excerpt

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe developmental defects, yet the molecular mechanisms explaining its effects on cellular physiology remain elusive. Here we show, using a series of human cells with defined aneuploid karyotypes, that gain of a single chromosome increases genomic instability. Next-generation sequencing and SNP-array analysis reveal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 5

Share to Chromosomes, Human, Pair 8

Share to HCT116 Cells

Share to Metaphase

Share to Minichromosome Maintenance Proteins

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 26876972
DOI: 10.1038/ncomms10754
PMCID: PMC4756715

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The presence of extra chromosomes leads to genomic instability.PMID 26876972Read ↗

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stabilitySemantic proximity Read ↗

Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancerSemantic proximity Read ↗

The Hallmarks of Aneuploidy in Cancer and Congenital SyndromesSemantic proximity Read ↗

Oncogene-like addiction to aneuploidy in human cancersSemantic proximity Read ↗

Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-TaijiSemantic proximity Read ↗

Mechanisms Generating Cancer Genome Complexity From A Single Cell Division ErrorSemantic proximity Read ↗

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer.Semantic proximity Read ↗

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cellsSemantic proximity Read ↗

Chromosome Abnormalities: New Insights into Their Clinical Significance in CancerSemantic proximity Read ↗

Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancerSemantic proximity Read ↗

The genomic characteristics and cellular origin of chromothripsis.Semantic proximity Read ↗

Oncogene-like addiction to aneuploidy in human cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.