Article

Modulation of Rac1/PAK1/connexin43-Mediated ATP Release from Astrocytes Contributes to Retinal Ganglion Cell Survival in Experimental Glaucoma

2021-08-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Connexin43 (Cx43) is one of major gap junction proteins in glial cells. Mutation in the gap junction protein alpha 1 gene of Cx43 has been detected in human glaucomatous retinas, suggestive of involvement of Cx43 in pathogenesis of glaucoma. However, the role of Cx43 in glaucoma has not been clearly elucidated. <bold>Methods: </bold>A mouse model of chronic ocul...

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Literature Corpus work: cc879225-fba7-506e-879b-6a89968ab08c
DOI: 10.21203/rs.3.rs-770147/v1

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