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Article

Connexin 43 hemichannels are permeable to ATP.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Apr 2008

Kang Jian, Kang Ning, Lovatt Ditte, Torres Arnulfo, Zhao Zhuo, Lin Jane, Nedergaard Maiken

Abstract excerpt

Astrocytes are electrically nonexcitable cells that communicate by means of Ca(2+) signaling. Long-distance intercellular Ca(2+) waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does not exist. Here, through several alternative approaches,...

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Identifiers

PMID: 18448647
DOI: 10.1523/JNEUROSCI.5048-07.2008
PMCID: PMC3638995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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