Article

The Adenosine A2A Receptor Antagonist KW6002 Mitigates Aldosterone-induced Central Serous Chorioretinopathy in Mice

2026-01-13

Abstract excerpt

<title>Abstract</title> Purpose Central serous chorioretinopathy (CSC), a prevalent disease characterized by choroidal vascular abnormalities, has extremely limited treatment options. This study investigates the effects of the selective adenosine A 2A receptor (A 2A R) antagonist KW6002 on choroidal vascular hyperpermeability and the blood-retinal barrier (BRB), and explores its th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09a9d6da-e63d-5c74-966f-b4c4da9d4afc
DOI: 10.21203/rs.3.rs-8526598/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Adenosine A2A Receptor Antagonist KW6002 Mitigates Aldosterone-induced Central Serous Chorioretinopathy in MiceDOI 10.21203/rs.3.rs-8526598/v1Read

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.Semantic proximity Read

CRISPR-CasRx-mediated disruption of Aqp1/Adrb2/Rock1/Rock2 genes reduces intraocular pressure and retinal ganglion cell damage in miceSemantic proximity Read

Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment EpitheliumSemantic proximity Read

Keep an eye on adenosine: Its role in retinal inflammationSemantic proximity Read

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesisSemantic proximity Read

VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and HumansSemantic proximity Read

Caveolin-1 Protects Retinal Ganglion Cells against Acute Ocular Hypertension Injury via Modulating Microglial Phenotypes and Distribution and Activating AKT pathway.Semantic proximity Read

A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytesSemantic proximity Read

Beta-Adrenoreceptor Agonism Influences Retinal Responses to Hypoxia in a Model of Retinopathy of PrematuritySemantic proximity Read

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin ReceptorSemantic proximity Read

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse EyesSemantic proximity Read

The choroidal nervous system: a link between mineralocorticoid receptor and pachychoroidSemantic proximity Read