Article
DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
Cell death & disease - 6 Aug 2015
Kim K-Y, Perkins G A, Shim M S, Bushong E, Alcasid N, Ju S, Ellisman M H, Weinreb R N, Ju W-K
Abstract excerpt
Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual function. Although oxidative stress and/or alteration of mitochondrial (mt) dynamics induced by elevated intraocular pressure (IOP) are associated with this neurodegenerative disease, the mechanisms that regulate...
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