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Article

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy

4 Nov 2022

Abstract excerpt

Astrocyte abnormalities have received great attention for their association with various diseases in the brain but not so much in the eye. Recent independent genome-wide association studies of glaucoma, optic neuropathy characterized by retinal ganglion cell (RGC) degeneration, and vision loss found that single-nucleotide polymorphisms near the ABCA1 locus were common risk factors. Here, we show that Abca1 loss...

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PMID: 36332025
DOI: 10.1126/sciadv.abq1081

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