Article

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction

2021-08-05

Abstract excerpt

<h4>ABSTRACT</h4> The transmembrane domain (TMD) of the amyloid precursor protein of Alzheimer’s disease is processively cut by γ-secretase through endoproteolysis and tricarboxypeptidase “trimming”. We recently developed a prototype substrate TMD mimetic for structural analysis—composed of a helical peptide inhibitor linked to a transition-state analog—that simultaneously engages a substrate exosite and the acti...

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Literature Corpus work: cc860f7c-8998-50e5-aeb0-4daf36db0b41
DOI: 10.1101/2021.08.05.455313

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