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Article

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Dec 2017

Cai Tetsuo, Yonaga Masahiro, Tomita Taisuke

Abstract excerpt

γ-Secretase is an intramembrane cleaving protease that is responsible for the generation of amyloid-β peptides, which are linked to the pathogenesis of Alzheimer disease. Recently, γ-secretase modulators (GSMs) have been shown to specifically decrease production of the aggregation-prone and toxic longer Aβ species, and concomitantly increase the levels of shorter Aβ. We previously found that phenylimidazole-type...

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Identifiers

PMID: 29118109
DOI: 10.1523/JNEUROSCI.1628-17.2017
PMCID: PMC6596819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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