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Article

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2005

Kornilova Anna Y, Bihel Frédéric, Das Chittaranjan, Wolfe Michael S

Abstract excerpt

gamma-Secretase is a structurally enigmatic multiprotein complex that catalyzes intramembrane proteolysis of a variety of substrates, including the amyloid beta-protein precursor of Alzheimer's disease and the Notch receptor essential to cell differentiation. The active site of this transmembrane aspartyl protease apparently lies at the interface between two subunits of presenilin-1 (PS1); however, evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15722417
DOI: 10.1073/pnas.0407640102
PMCID: PMC552920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.PMID 15722417Read ↗

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Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Semantic proximity Read ↗

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate InteractionSemantic proximity Read ↗

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Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Semantic proximity Read ↗

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