Article

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

2023-12-13

Abstract excerpt

<title>Abstract</title> <p>Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by selecting substrates and decorating them with distinct ubiquitin signals. Structure determination of the underlying, specific E3-substrate complexes, however, has proven challenging due to their transient nature. In particular, it is incompletely understood how members of the catalytic cysteine-drive...

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Literature Corpus work: 61248636-0757-5795-9952-32e473218ecd
DOI: 10.21203/rs.3.rs-3220888/v1

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