Article

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

2018-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Since conformational flexibility of a di-glycine hinge in the C99 transmembrane domain (TMD) might be critical for γ-secretase cleavage, we mutated one of the glycine residues, G38, to a helix-stabilizing leucine and to a helix-distorting proline. CD, NMR and...

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Literature Corpus work: c3b89771-0c43-5219-96e7-7e38b5a16ae7
DOI: 10.1101/375006

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