Article

The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study

2016-06-13

Abstract excerpt

Obesity is linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behavior of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood. We model how hyperinsulinemia alters the dynamics of the CD4+ T regulatory network, and this, in turn, modulates cell differ...

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Literature Corpus work: cc711c0b-f5ed-51c9-8b79-1f7ce2d48da3
DOI: 10.1101/058743

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