Article

Hyperinsulinemia counteracts inflammation by suppressing IFNγ and inducing senescence in CD4<sup>+</sup>T cells of patients with rheumatoid arthritis

2024-03-10

Abstract excerpt

<h4>Background</h4> Clinical evidence connects hyperinsulinemia with obesity, and development of type 2 diabetes (T2D). However, its role in autoimmune conditions was questioned. We investigated consequences of hyperinsulinemia for development of T2D and CD4 T cell function in rheumatoid arthritis (RA). <h4>Methods</h4> Incident T2D was prospectively studied in two independent RA cohorts and in gout patients match...

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Literature Corpus work: 01d65676-f529-5323-9f52-bd0da76307db
DOI: 10.1101/2024.03.08.24303970

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