Article

Exploring the intrinsic and extrinsic determinants of heterogeneity in a <i>β</i> -cell network

2025-10-26

Abstract excerpt

Pancreatic islets are micro-organs composed of multiple endocrine cell types. β -cells are the most common of these and are highly heterogeneous in both their intrinsic properties, such as ion channel conductances and metabolic activity, and extrinsic properties, including gap junction coupling and paracrine signaling. Capturing these diverse sources of heterogeneity is essential for computational models that aim...

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Literature Corpus work: 89ab074a-2bfa-5c03-b926-911564f67bf2
DOI: 10.1101/2025.10.26.684303

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