Article
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.
PLoS computational biology - 1 Apr 2013
Carbo Adria, Hontecillas Raquel, Kronsteiner Barbara, Viladomiu Monica, Pedragosa Mireia, Lu Pinyi, Philipson Casandra W, Hoops Stefan, Marathe Madhav, Eubank Stephen, Bisset Keith, Wendelsdorf Katherine, Jarrah Abdul, Mei Yongguo, Bassaganya-Riera Josep
Abstract excerpt
Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches and computational modeling to investigate the mechanisms controlling differentiation and plasticity of CD4+ T cells in the gut of mice. Our computational model encompasses the major...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.