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Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

1 Apr 2019

Abstract excerpt

BACKGROUND: Major alteration in lifestyle of human population has promoted Type 2 diabetes mellitus (T2DM) to the level of an epidemic. This metabolic disorder is characterized by insulin resistance and pancreatic β-cell dysfunction and apoptosis, triggered by endoplasmic reticulum (ER) stress, oxidative stress and cytokines. Computational modeling is necessary to consolidate information from various sources in...

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PMID: 30953496
DOI: 10.1186/s12918-019-0692-0

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