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Article

Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation.

Molecular biology of the cell - 15 May 2022

Duddu Atchuta Srinivas, Majumdar Sauma Suvra, Sahoo Sarthak, Jhunjhunwala Siddharth, Jolly Mohit Kumar

Abstract excerpt

Naïve helper (CD4+) T-cells can differentiate into distinct functional subsets including Th1, Th2, and Th17 phenotypes. Each of these phenotypes has a "master regulator"-T-bet (Th1), GATA3 (Th2), and RORγT (Th17)-that inhibits the other two master regulators. Such mutual repression among them at a transcriptional level can enable multistability, giving rise to six experimentally observed phenotype, Th1, Th2,...

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Identifiers

PMID: 35353012
DOI: 10.1091/mbc.E21-10-0521
PMCID: PMC9265159

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