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Article

The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.

Immunology - 1 Apr 2018

Sadreev Ildar I, Chen Michael Z Q, Umezawa Yoshinori, Biktashev Vadim N, Kemper Claudia, Salakhieva Diana V, Welsh Gavin I, Kotov Nikolay V

Abstract excerpt

Signal transducers and activators of transcription (STATs) are key molecular determinants of T-cell fate and effector function. Several inflammatory diseases are characterized by an altered balance of T-cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms by which the same STAT proteins regulate both the...

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PMID: 29030870
DOI: 10.1111/imm.12851
PMCID: PMC5838427

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