Article

Tipping-point transition from transient to persistent inflammation in pancreatic islets

2024-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes (T2D) is associated with a systemic increase in the pro-inflammatory cytokine IL-1β. While transient exposure to low IL-1β concentrations improves insulin secretion and β-cell proliferation in pancreatic islets, prolonged exposure leads to impaired insulin secretion and collective β-cell death. IL-1 is secreted locally by islet-resident macrophages and β-cells; however it is unkn...

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Literature Corpus work: 9581d729-4171-55f1-9992-2678a7fea0cb
DOI: 10.1101/2024.03.10.584271

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