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Article

A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells.

PLoS computational biology - 1 Jul 2011

Hong Tian, Xing Jianhua, Li Liwu, Tyson John J

Abstract excerpt

The reciprocal differentiation of T helper 17 (T(H)17) cells and induced regulatory T (iT(reg)) cells plays a critical role in both the pathogenesis and resolution of diverse human inflammatory diseases. Although initial studies suggested a stable commitment to either the T(H)17 or the iT(reg) lineage, recent results reveal remarkable plasticity and heterogeneity, reflected in the capacity of differentiated...

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PMID: 21829337
DOI: 10.1371/journal.pcbi.1002122
PMCID: PMC3145653

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