Article

Multi-Approach and Multi-Scale Model of CD4+ T Cells Predicts Switch-Like and Oscillatory Emergent Behaviors in Inflammatory Response to Infection

2020-02-27

Abstract excerpt

Immune responses rely on a complex adaptive system in which the body and infections interact at multiple scales and in different compartments. We developed a modular model of CD4+ T cells which uses four modeling approaches to integrate processes taking place at three spatial scales in different tissues. In each cell, signal transduction and gene regulation are described by a logical model, metabolism by constrain...

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Literature Corpus work: 9dff1709-2e1c-5f13-af98-9f246bc46a3a
DOI: 10.1101/2020.02.26.964502

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