Article

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in <i>cis</i>

2017-05-31

Abstract excerpt

Across mammals, PRDM9 binding localizes almost all meiotic recombination hotspots. However, most PRDM9 motif sequence matches are not bound, and most PRDM9-bound loci do not become hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human and chimp PRDM9 binding sites in a human cell line, and measured PRDM9-induced H3K4me3 and gene expression changes. These data revea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc112569-8a07-56cc-b53d-e37aeed039d5
DOI: 10.1101/144295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in <i>cis</i>DOI 10.1101/144295Read

PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.Semantic proximity Read

Prdm9 controls activation of mammalian recombination hotspots.Semantic proximity Read

DNA binding specificities of the long zinc-finger recombination protein PRDM9.Semantic proximity Read

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans.Semantic proximity Read

<i>PRDM9</i> losses in vertebrates are coupled to those of paralogs <i>ZCWPW1</i> and <i>ZCWPW2</i>Semantic proximity Read

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repairSemantic proximity Read

The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans.Semantic proximity Read

Structural basis for human PRDM9 action at recombination hot spots.Semantic proximity Read

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.Semantic proximity Read

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.Semantic proximity Read

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations.Semantic proximity Read

Genetic recombination is directed away from functional genomic elements in mice.Semantic proximity Read