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Article

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans.

Nature genetics - 1 Oct 2010

Berg Ingrid L, Neumann Rita, Lam Kwan-Wood G, Sarbajna Shriparna, Odenthal-Hesse Linda, May Celia A, Jeffreys Alec J

Abstract excerpt

PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in humans and mice. PRDM9 contains a zinc finger array that, in humans, can recognize a short sequence motif associated with hot spots, with binding to this motif possibly triggering hot-spot activity via chromatin remodeling. We now report that human genetic variation at the PRDM9 locus has a strong effect on sperm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20818382
DOI: 10.1038/ng.658
PMCID: PMC3092422

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans.PMID 20818382Read ↗

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Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.Semantic proximity Read ↗

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