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Article

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.

PLoS genetics - 1 Sept 2015

Baker Christopher L, Petkova Pavlina, Walker Michael, Flachs Petr, Mihola Ondrej, Trachtulec Zdenek, Petkov Petko M, Paigen Kenneth

Abstract excerpt

Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed hotspots, whose locations are determined by PRDM9, a zinc finger DNA-binding histone methyltransferase. Prdm9 is highly polymorphic with most alleles activating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26368021
DOI: 10.1371/journal.pgen.1005512
PMCID: PMC4569383

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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