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Article

The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans.

PLoS biology - 1 Dec 2011

Ségurel Laure, Leffler Ellen Miranda, Przeworski Molly

Abstract excerpt

During mammalian meiosis, double-strand breaks are deliberately made throughout the genome and then repaired, leading to the exchange of genetic material between copies of chromosomes. How the locations of breaks are specified was largely unknown until a fortuitous confluence of statistical genetics and molecular biology uncovered the role of PRDM9, a DNA binding protein. Many properties of this protein remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22162947
DOI: 10.1371/journal.pbio.1001211
PMCID: PMC3232208

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans.PMID 22162947Read ↗

PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.Semantic proximity Read ↗

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in <i>cis</i>Semantic proximity Read ↗

Prdm9 controls activation of mammalian recombination hotspots.Semantic proximity Read ↗

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Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations.Semantic proximity Read ↗

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repairSemantic proximity Read ↗

<i>PRDM9</i> losses in vertebrates are coupled to those of paralogs <i>ZCWPW1</i> and <i>ZCWPW2</i>Semantic proximity Read ↗

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Structural basis for human PRDM9 action at recombination hot spots.Semantic proximity Read ↗

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