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Article

Genetic recombination is directed away from functional genomic elements in mice.

Nature - 13 May 2012

Brick Kevin, Smagulova Fatima, Khil Pavel, Camerini-Otero R Daniel, Petukhova Galina V

Abstract excerpt

Genetic recombination occurs during meiosis, the key developmental programme of gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 methyltransferase, PR domain containing 9 (PRDM9), the product of the only known speciation-associated gene in mammals. PRDM9 is thought to determine the preferred recombination sites--recombination hotspots--through sequence-specific...

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Identifiers

PMID: 22660327
DOI: 10.1038/nature11089
PMCID: PMC3367396

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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