Article
Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011
Berg Ingrid L, Neumann Rita, Sarbajna Shriparna, Odenthal-Hesse Linda, Butler Nicola J, Jeffreys Alec J
Abstract excerpt
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9 regulation, in terms of motifs defined and hotspots studied, has a strong bias toward the PRDM9 A variant particularly common in Europeans. We show that population diversity can reveal a second class of hotspots...
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