Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.

Science (New York, N.Y.) - 12 Feb 2010

Myers Simon, Bowden Rory, Tumian Afidalina, Bontrop Ronald E, Freeman Colin, MacFie Tammie S, McVean Gil, Donnelly Peter

Abstract excerpt

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crossing Over, Genetic
Share to Histone-Lysine N-Methyltransferase
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meiosis

Share to Methylation

Share to Pan troglodytes

Share to Recombination, Genetic

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 20044541
DOI: 10.1126/science.1182363
PMCID: PMC3828505

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20044541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.PMID 20044541Read ↗

PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.Semantic proximity Read ↗

Prdm9 controls activation of mammalian recombination hotspots.Semantic proximity Read ↗

Stable recombination hotspots in birdsSemantic proximity Read ↗

Primate evolution of the recombination regulator PRDM9.Semantic proximity Read ↗

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans.Semantic proximity Read ↗

High prevalence of Prdm9-independent recombination hotspots in placental mammalsSemantic proximity Read ↗

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.Semantic proximity Read ↗

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations.Semantic proximity Read ↗

The landscape of recombination in African Americans.Semantic proximity Read ↗

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in <i>cis</i>Semantic proximity Read ↗

A fine-scale chimpanzee genetic map from population sequencing.Semantic proximity Read ↗

Down the Penrose stairs: How selection for fewer recombination hotspots maintains their existenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.