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Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure

8 May 2020

Abstract excerpt

Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce mutations, as well as identifying factors that affect their efficiency and fidelity is key to developing this technology for therapeutic uses. Here, we discuss...

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PMID: 32457906
DOI: 10.3389/fcell.2020.00319

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