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CRISPRoff epigenetic editing for programmable gene silencing in human cells without DNA breaks

2024-09-09

Abstract excerpt

The advent of CRISPR-based technologies has enabled the rapid advancement of programmable gene manipulation in cells, tissues, and whole organisms. An emerging platform for targeted gene perturbation is epigenetic editing, the direct editing of chemical modifications on DNA and histones that ultimately results in repression or activation of the targeted gene. In contrast to CRISPR nucleases, epigenetic editors mod...

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Literature Corpus work
d9983251-e2b5-5a75-be09-02f0be8842b5
DOI
10.1101/2024.09.09.612111
Open publication

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CRISPRoff epigenetic editing for programmable gene silencing in human cells without DNA breaksDOI 10.1101/2024.09.09.612111
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