Article

Mutability and hypermutation antagonize immunoglobulin codon optimality

2024-03-14

Abstract excerpt

The efficacy of polyclonal antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation (SHM). These processes arose in early jawed vertebrates; however, little is known about how immunoglobulin diversity, mutability, and hypermutation have evolved in tandem with another more ubiquitous feature of protein-coding DNA – codon optimality. Here, we e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbdc6a52-8bb5-561a-a700-8702f9d4ebf8
DOI: 10.1101/2024.03.13.584690

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutability and hypermutation antagonize immunoglobulin codon optimalityDOI 10.1101/2024.03.13.584690Read

Mutability and hypermutation antagonize immunoglobulin codon optimality.Semantic proximity Read

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic HypermutationSemantic proximity Read

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine DesignSemantic proximity Read

Synonymous mutations in viral evolution and vaccine design.Semantic proximity Read

Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution.Semantic proximity Read

Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.Semantic proximity Read

Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral EvolutionSemantic proximity Read

Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibodySemantic proximity Read

B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.Semantic proximity Read

Antibody-specific model of amino acid substitution for immunological inferences from alignments of antibody sequences.Semantic proximity Read

Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus.Semantic proximity Read

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires.Semantic proximity Read