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Article

Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus.

Cell host & microbe - 15 Nov 2012

Lauring Adam S, Acevedo Ashley, Cooper Samantha B, Andino Raul

Abstract excerpt

RNA viruses exist as dynamic and diverse populations shaped by constant mutation and selection. Yet little is known about how the mutant spectrum contributes to virus evolvability and pathogenesis. Because several codon choices are available for a given amino acid, a central question concerns whether viral sequences have evolved to optimize not only the protein coding consensus, but also the DNA/RNA sequences...

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Identifiers

PMID: 23159052
DOI: 10.1016/j.chom.2012.10.008
PMCID: PMC3504468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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