Article
B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.
Molecular immunology - 1 May 2015
Saini Jasmine, Hershberg Uri
Abstract excerpt
The exceptional ability of B cells to diversify through somatic mutation and improve affinity of the repertoire toward the antigens is the cornerstone of adaptive immunity. Somatic mutation is not evenly distributed and exhibits certain micro-sequence specificities. We show here that the combinat...
Topics
- Adaptive Immunity
- Aging
- Antibody Affinity
- B-Lymphocytes
- Complementarity Determining Regions
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mutation
- Receptors, Antigen, B-Cell
- Receptors, Antigen, T-Cell
- Somatic Hypermutation, Immunoglobulin