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Article

Antibody-specific model of amino acid substitution for immunological inferences from alignments of antibody sequences.

Molecular biology and evolution - 1 Mar 2015

Mirsky Alexander, Kazandjian Linda, Anisimova Maria

Abstract excerpt

Antibodies are glycoproteins produced by the immune system as a dynamically adaptive line of defense against invading pathogens. Very elegant and specific mutational mechanisms allow B lymphocytes to produce a large and diversified repertoire of antibodies, which is modified and enhanced throughout all adulthood. One of these mechanisms is somatic hypermutation, which stochastically mutates nucleotides in the...

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Identifiers

PMID: 25534034
DOI: 10.1093/molbev/msu340
PMCID: PMC4327158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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