Antibody-specific model of amino acid substitution for immunological inferences from alignments of antibody sequences.

Abstract excerpt

Antibodies are glycoproteins produced by the immune system as a dynamically adaptive line of defense against invading pathogens. Very elegant and specific mutational mechanisms allow B lymphocytes to produce a large and diversified repertoire of antibodies, which is modified and enhanced througho...

Topics

• Amino Acid Sequence
• Amino Acid Substitution
• Animals
• Antibodies
• Databases, Protein
• Evolution, Molecular
• Humans
• Markov Chains
• Mice
• Molecular Sequence Data
• Mutation
• Sequence Alignment