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Article

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires.

mAbs - 1 Jan 2000

Schmitz Samuel, Soto Cinque, Crowe James E, Meiler Jens

Abstract excerpt

The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire. It is common to characterize single nucleotide frequencies of the variable region by alignment to species-specific wildtype germline genes. The increasing application of next-generation sequencing to immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32397786
DOI: 10.1080/19420862.2020.1758291
PMCID: PMC8648325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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