Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design

Abstract excerpt

The evolution of antibodies in an individual during an immune response by somatic hypermutation (SHM) is essential for the ability of the immune system to recognize and remove the diverse spectrum of antigens that may be encountered. These mutations are not produced at random; nucleotide motifs which result in increased or decreased rates of mutation were first reported in 1992. Newer models that estimate the...

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