Article

Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody

2025-03-11

Abstract excerpt

<h4>SUMMARY</h4> Public antibodies that recognize conserved epitopes are critical for vaccine development, and identifying somatic hypermutations (SHMs) that enhance antigen affinity in these public responses is key to guiding vaccine design for better protection. We propose that affinity-enhancing SHMs are selectively enriched in public antibody clonotypes, surpassing the background frequency seen in antibodies...

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Identifiers and source

Literature Corpus work: 64fd4c05-3879-5bcd-85b9-47337a881d71
DOI: 10.1101/2025.03.07.642041

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