Mutability and hypermutation antagonize immunoglobulin codon optimality.

doi:10.1016/j.molcel.2024.11.033

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Article

Mutability and hypermutation antagonize immunoglobulin codon optimality.

Molecular cell - 16 Jan 2025

McGrath Joshua J C, Park Juyeon, Troxell Chloe A, Chervin Jordan C, Li Lei, Kent Johnathan R, Changrob Siriruk, Fu Yanbin, Huang Min, Zheng Nai-Ying, Wilbanks G Dewey, Nelson Sean A, Sun Jiayi, Inghirami Giorgio, Madariaga Maria Lucia L, Georgiou George, Wilson Patrick C

Abstract excerpt

The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Despite this, it is unclear how genetic diversification mechanisms evolved alongside codon optimality and affect antibody expression. Here, we analyze germline immunoglobulin (IG) genes, natural V(D)J repertoires, serum IgG, and monoclonal antibody (mAb) expression...

Topics

Animals
Humans
Mice
Somatic Hypermutation, Immunoglobulin
Codon
SARS-CoV-2
Immunoglobulin Variable Region
Zebrafish
Antibodies, Monoclonal
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

COVID-19

V(D)J Recombination

Immunoglobulin G

HIV-1

Complementarity Determining Regions

Source

Open in PubMed Open full text

Identifiers

PMID: 39708804
DOI: 10.1016/j.molcel.2024.11.033
PMCID: PMC12063209

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39708804-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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