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Article

Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution.

Cell reports - 27 Jan 2026

Dingus John, Yoo Duck-Kyun, Kumar Sachin, Wang Yajuan, Kibria Md Golam, Saghaei Shahab, Allahyari Zahra, Chen Jessica W, Caputo Natalie M, Hwang Jason, Chen Bing, Wesemann Duane R

Abstract excerpt

A key goal of vaccinology is to train the immune system to combat current pathogens while preparing it for future variants. Here, we investigate how Wuhan strain severe acute respiratory syndrome coronavirus 2 mRNA vaccination generates "anticipatory breadth" in an antibody family exhibiting germline complementarity to the ACE2 binding site on the receptor-binding-domain (RBD). IGHV3-53/66 antibodies from...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41474620
DOI: 10.1016/j.celrep.2025.116800
PMCID: PMC12952975

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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