Article

Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution

2025-08-28

Abstract excerpt

A key goal of vaccinology is to train the immune system to combat current pathogens while simultaneously preparing it for future evolved variants. Understanding factors contributing to anticipatory breadth, wherein affinity maturation against an ancestral strain yields neutralization capacity against evolved variants, is therefore of great importance. Here, we investigated the mechanism of anticipatory breadth dev...

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Literature Corpus work: 43730cba-4b38-565b-948b-4780ce7a1de1
DOI: 10.1101/2025.08.27.672735

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