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Article

Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.

Genome research - 1 Dec 1999

Oprea M, Kepler T B

Abstract excerpt

Evidence for somatic hypermutation of immunoglobulin genes has been observed in all of the species in which immunoglobulins have been found. Previous studies have suggested that codon usage in immunoglobulin variable (V) region genes is such that the sequence-specificity of somatic hypermutation results in greater mutability in complementarity-determining regions of the gene than in the framework regions. We have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10613852
DOI: 10.1101/gr.9.12.1294
PMCID: PMC310983

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Source receipt: pubmed, retrieved 7 Sept 2026.

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