Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.

doi:10.1101/gr.9.12.1294

Back to search

Article

Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.

Genome research - 1 Dec 1999

Oprea M, Kepler T B

Abstract excerpt

Evidence for somatic hypermutation of immunoglobulin genes has been observed in all of the species in which immunoglobulins have been found. Previous studies have suggested that codon usage in immunoglobulin variable (V) region genes is such that the sequence-specificity of somatic hypermutation...

Topics

Base Sequence
Codon
Computational Biology
Genes, T-Cell Receptor
Humans
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
Phylogeny
Sequence Analysis, DNA

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.